A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131

The increase of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options for AMR pathogens increasingly attractive. Recent studies have demonstrated anti-bacterial efficacy of a humanised monoclonal antibody (mAb) targeting the O25b...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Maes, Mailis, Dyson, Zoe A., Smith, Sarah E., Goulding, David A., Ludden, Catherine, Baker, Stephen, Kellam, Paul, Reece, Stephen T., Dougan, Gordon, Bartholdson Scott, Josefin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382476/
https://ncbi.nlm.nih.gov/pubmed/32709982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69300-8
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