Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker

Nucleic acid aptamers selected through systematic evolution of ligands by exponential enrichment (SELEX) fold into exquisite globular structures in complex with protein targets with diverse translational applications. Varying the chemistry of nucleotides allows evolution of nonnatural nucleic acids,...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cheung, Yee-Wai, Röthlisberger, Pascal, Mechaly, Ariel E., Weber, Patrick, Levi-Acobas, Fabienne, Lo, Young, Wong, Alvin W. C., Kinghorn, Andrew B., Haouz, Ahmed, Savage, G. Paul, Hollenstein, Marcel, Tanner, Julian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382308/
https://ncbi.nlm.nih.gov/pubmed/32631977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003267117
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