Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation

Affinity maturation is a powerful technique in antibody engineering for the in vitro evolution of antigen binding interactions. Key to the success of this process is the expansion of sequence and combinatorial diversity to increase the structural repertoire from which superior binding variants may b...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382286/
https://ncbi.nlm.nih.gov/pubmed/32616569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919565117
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items