Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex

Rubicon is a potent negative regulator of autophagy and a potential target for autophagy-inducing therapeutics. Rubicon-mediated inhibition of autophagy requires the interaction of the C-terminal Rubicon homology (RH) domain of Rubicon with Rab7–GTP. Here we report the 2.8-Å crystal structure of the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bhargava, Hersh K., Tabata, Keisuke, Byck, Jordan M., Hamasaki, Maho, Farrell, Daniel P., Anishchenko, Ivan, DiMaio, Frank, Im, Young Jun, Yoshimori, Tamotsu, Hurley, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382272/
https://ncbi.nlm.nih.gov/pubmed/32632011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008030117
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