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Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells
Semi-invariant natural killer T (iNKT) cells are self-reactive lymphocytes, yet how this lineage attains self-tolerance remains unknown. iNKT cells constitutively express high levels of Nr4a1-encoded Nur77, a transcription factor that integrates signal strength downstream of the T cell receptor (TCR...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7382224/ https://ncbi.nlm.nih.gov/pubmed/32611812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001665117 |
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