Alterations in the intrinsic properties of striatal cholinergic interneurons after dopamine lesion and chronic L-DOPA

Changes in striatal cholinergic interneuron (ChI) activity are thought to contribute to Parkinson’s disease pathophysiology and dyskinesia from chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, but the physiological basis of these changes is unknown. We find that dopamine lesion decreases the...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Choi, Se Joon, Ma, Thong C, Ding, Yunmin, Cheung, Timothy, Joshi, Neal, Sulzer, David, Mosharov, Eugene V, Kang, Un Jung
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380940/
https://ncbi.nlm.nih.gov/pubmed/32687053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56920
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