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Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias

L-dopa-induced dyskinesias (LIDs) are a serious complication of L-dopa therapy for Parkinson's disease. Emerging evidence indicates that the nicotinic cholinergic system plays a role in LIDs, although the pathways and mechanisms are poorly understood. Here we used optogenetics to investigate th...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Bordia, Tanuja, Perez, Xiomara A., Heiss, Jaime, Zhang, Danhui, Quik, Maryka
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860059/
https://ncbi.nlm.nih.gov/pubmed/26921469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.02.019
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