Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity

Retinal ganglion cell (RGC) loss and optic neuropathy, both hallmarks of glaucoma, have been shown to involve N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity. This study investigated the neuroprotective effects of Philanthotoxin (PhTX)-343 in NMDA-induced retinal injury to alleviate en...

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Udgivet i:PLoS One
Main Authors: Fazel, Muhammad Fattah, Abu, Izuddin Fahmy, Mohamad, Mohamad Haiqal Nizar, Agarwal, Renu, Iezhitsa, Igor, Bakar, Nor Salmah, Juliana, Norsham, Mellor, Ian R., Franzyk, Henrik
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380593/
https://ncbi.nlm.nih.gov/pubmed/32706792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0236450
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