Napabucasin (BBI 608) a Potent Chemoradio-Sensitizer in Rectal Cancer

BACKGROUND: Induction of reactive oxygen species (ROS) represents a viable strategy to enhance the activity of radiotherapy. We hypothesized that napabucasin would increase ROS via its ability to inhibit NAD(P)H:quinone oxidoreductase 1 (NQO1) and potentiate the response to chemoradiotherapy in rect...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Nagaraju, Ganji Purnachandra, Farran, Batoul, Farren, Matthew, Chalikonda, Gayathri, Wu, Christina, Lesinski, Gregory B., El-Rayes, Bassel F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380507/
https://ncbi.nlm.nih.gov/pubmed/32383803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.32954
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