HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy

Cell cycle progression and DNA synthesis are essential steps in cancer cell growth. Thymidylate synthase (TS) is a therapeutic target for 5FU. We tested the hypothesis that HSP90 transcriptional and functional inhibition can inhibit cell cycle progression, downregulate TS levels and sensitize colore...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nagaraju, Ganji Purnachandra, Alese, Olatunji B., Landry, Jerome, Diaz, Roberto, El-Rayes, Bassel F
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259452/
https://ncbi.nlm.nih.gov/pubmed/25296971
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