Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α

Activation of lipid-burning pathways in the fat-storing white adipose tissue (WAT) is a promising strategy to improve metabolic health and reduce obesity, insulin resistance, and type II diabetes. For unknown reasons, bilirubin levels are negatively associated with obesity and diabetes. Here, using...

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Publicado en:J Biol Chem
Autores principales: Gordon, Darren M., Neifer, Kari L., Hamoud, Abdul-Rizaq Ali, Hawk, Charles F., Nestor-Kalinoski, Andrea L., Miruzzi, Scott A., Morran, Michael P., Adeosun, Samuel O., Sarver, Jeffrey G., Erhardt, Paul W., McCullumsmith, Robert E., Stec, David E., Hinds, Terry D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380202/
https://ncbi.nlm.nih.gov/pubmed/32404366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013700
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