RNA sequencing in human HepG2 hepatocytes reveals PPAR-α mediates transcriptome responsiveness of bilirubin

Bilirubin is a potent antioxidant that reduces inflammation and the accumulation of fat. There have been reports of gene responses to bilirubin, which was mostly attributed to its antioxidant function. Using RNA sequencing, we found that biliverdin, which is rapidly reduced to bilirubin, induced tra...

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Vydáno v:Physiol Genomics
Hlavní autoři: Gordon, Darren M., Blomquist, Thomas M., Miruzzi, Scott A., McCullumsmith, Robert, Stec, David E., Hinds, Terry D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
Témata:
Rapid Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620644/
https://ncbi.nlm.nih.gov/pubmed/31074682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00028.2019
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