Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

AIMS/INTRODUCTION: Under irremediable endoplasmic reticulum (ER) stress, hyperactivated inositol‐requiring enzyme 1α (IRE1α) triggers the terminal unfolded protein response (T‐UPR), causing crucial cell dysfunction and apoptosis. We hypothesized that nicotinic acetylcholine receptor (nAChR) signalin...

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Julkaisussa:J Diabetes Investig
Päätekijät: Ishibashi, Tatsuya, Morita, Shuhei, Kishimoto, Shohei, Uraki, Shinsuke, Takeshima, Ken, Furukawa, Yasushi, Inaba, Hidefumi, Ariyasu, Hiroyuki, Iwakura, Hiroshi, Furuta, Hiroto, Nishi, Masahiro, Papa, Feroz R, Akamizu, Takashi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378412/
https://ncbi.nlm.nih.gov/pubmed/31925927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jdi.13211
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