Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

AIMS/INTRODUCTION: Under irremediable endoplasmic reticulum (ER) stress, hyperactivated inositol‐requiring enzyme 1α (IRE1α) triggers the terminal unfolded protein response (T‐UPR), causing crucial cell dysfunction and apoptosis. We hypothesized that nicotinic acetylcholine receptor (nAChR) signalin...

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Detalhes bibliográficos
Publicado no:J Diabetes Investig
Main Authors: Ishibashi, Tatsuya, Morita, Shuhei, Kishimoto, Shohei, Uraki, Shinsuke, Takeshima, Ken, Furukawa, Yasushi, Inaba, Hidefumi, Ariyasu, Hiroyuki, Iwakura, Hiroshi, Furuta, Hiroto, Nishi, Masahiro, Papa, Feroz R, Akamizu, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378412/
https://ncbi.nlm.nih.gov/pubmed/31925927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jdi.13211
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