Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Virotherapy using oncolytic adenovirus is an effective anticancer strategy. However, the tumor selectivity of oncolytic adenoviruses is not enough high. To develop oncolytic adenovirus with a low risk of off-tumor toxicity, we constructed a photoactivatable oncolytic adenovirus (paOAd). In response...

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Udgivet i:Cell Death Dis
Main Authors: Hagihara, Yasuko, Sakamoto, Ayaka, Tokuda, Takashi, Yamashita, Tomoki, Ikemoto, Sena, Kimura, Ayaka, Haruta, Makito, Sasagawa, Kiyotaka, Ohta, Jun, Takayama, Kazuo, Mizuguchi, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378209/
https://ncbi.nlm.nih.gov/pubmed/32703933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02782-6
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