Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging and poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis and fibrosis. Here we test the hypothesis that decreased cord Klotho levels in p...

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Publicado no:Sci Rep
Main Authors: Batlahally, Sunil, Franklin, Andrew, Damianos, Andreas, Huang, Jian, Chen, Pingping, Sharma, Mayank, Duara, Joanne, Keerthy, Divya, Zambrano, Ronald, Shehadeh, Lina A., Martinez, Eliana C., DeFreitas, Marissa J., Kulandavelu, Shathiyah, Abitbol, Carolyn L., Freundlich, Michael, Kanashiro-Takeuchi, Rosemeire M., Schmidt, Augusto, Benny, Merline, Wu, Shu, Mestan, Karen K., Young, Karen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378054/
https://ncbi.nlm.nih.gov/pubmed/32704023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69296-1
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