Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options. The lack of mouse models that recapitulate the genetics of ACC has hampered progress in the field. We analyzed The Cancer Genome Atlas (TCGA) dataset for ACC and found that patients harboring alterat...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Borges, Kleiton Silva, Pignatti, Emanuele, Leng, Sining, Kariyawasam, Dulanjalee, Ruiz-Babot, Gerard, Ramalho, Fernando Silva, Taketo, Makoto Mark, Carlone, Diana L., Breault, David T.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Brief Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378041/
https://ncbi.nlm.nih.gov/pubmed/32561853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1358-5
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