Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with limited therapeutic options. The lack of mouse models that recapitulate the genetics of ACC has hampered progress in the field. We analyzed The Cancer Genome Atlas (TCGA) dataset for ACC and found that patients harboring alterat...

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Bibliographic Details
Published in:Oncogene
Main Authors: Borges, Kleiton Silva, Pignatti, Emanuele, Leng, Sining, Kariyawasam, Dulanjalee, Ruiz-Babot, Gerard, Ramalho, Fernando Silva, Taketo, Makoto Mark, Carlone, Diana L., Breault, David T.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378041/
https://ncbi.nlm.nih.gov/pubmed/32561853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1358-5
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