Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Cell senescence is a chronic process associated with age-related degenerative diseases such as osteoarthritis (OA). Senescent cells (SnCs) accumulate in the articular cartilage and synovium, leading to OA pathologies. The accumulation of SnCs in the cartilage results in a senescence-associated secre...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Yang, Hao, Chen, Cheng, Chen, Hao, Duan, Xiaojun, Li, Juan, Zhou, Yi, Zeng, Weinan, Yang, Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377880/
https://ncbi.nlm.nih.gov/pubmed/32611834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103177
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