Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer’s disease

BACKGROUND: Muramyl dipeptide (MDP) is a component derived from minimal peptidoglycan motif from bacteria, and it is a ligand for the NOD2 receptor. Peripheral administration of MDP converts Ly6C(high) into Ly6C(low) monocytes. Previously, we have shown that Ly6C(low) monocytes play crucial roles in...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Fani Maleki, Adham, Cisbani, Giulia, Plante, Marie-Michèle, Préfontaine, Paul, Laflamme, Nataly, Gosselin, Jean, Rivest, Serge
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376735/
https://ncbi.nlm.nih.gov/pubmed/32698829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01893-3
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