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Unique genomic and neoepitope landscapes across tumors: a study across time, tissues, and space within a single lynch syndrome patient

Lynch syndrome (LS) arises in patients with pathogenic germline variants in DNA mismatch repair genes. LS is the most common inherited cancer predisposition condition and confers an elevated lifetime risk of multiple cancers notably colorectal and endometrial carcinomas. A distinguishing feature of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Phung, Tanya N., Lenkiewicz, Elizabeth, Malasi, Smriti, Sharma, Amit, Anderson, Karen S., Wilson, Melissa A., Pockaj, Barbara A., Barrett, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376229/
https://ncbi.nlm.nih.gov/pubmed/32699259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68939-7
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