Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia

The mutational spectrum and prognostic factors of NRAS-mutated (NRAS(mut)) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovered 152 NRAS(mut) AML (13%). Of the 152 NRAS(mut) AML, 89% had at least one companion mu...

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Pubblicato in:Sci Rep
Autori principali: Wang, Shujuan, Wu, Zhenzhen, Li, Tao, Li, Yafei, Wang, Weiqiong, Hao, Qianqian, Xie, Xinsheng, Wan, Dingming, Jiang, Zhongxing, Wang, Chong, Liu, Yanfang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376066/
https://ncbi.nlm.nih.gov/pubmed/32699322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69194-6
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