Cellular sensing of extracellular purine nucleosides triggers an innate IFN-β response

Mechanisms linking immune sensing of DNA danger signals in the extracellular environment to innate pathways in the cytosol are poorly understood. Here, we identify a previously unidentified immune-metabolic axis by which cells respond to purine nucleosides and trigger a type I interferon-β (IFN-β) r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Dhanwani, Rekha, Takahashi, Mariko, Mathews, Ian T., Lenzi, Camille, Romanov, Artem, Watrous, Jeramie D., Pieters, Bartijn, Hedrick, Catherine C., Benedict, Chris A., Linden, Joel, Nilsson, Roland, Jain, Mohit, Sharma, Sonia
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375821/
https://ncbi.nlm.nih.gov/pubmed/32743071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba3688
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