Increased PIP3 activity blocks nanoparticle mRNA delivery

The biological pathways that affect drug delivery in vivo remain poorly understood. We hypothesized that altering cell metabolism with phosphatidylinositol (3,4,5)-triphosphate (PIP3), a bioactive lipid upstream of the metabolic pathway PI3K (phosphatidylinositol 3-kinase)/AKT/ mTOR (mammalian targe...

Full description

Saved in:
Bibliographic Details
Published in:Sci Adv
Main Authors: Paunovska, Kalina, Da Silva Sanchez, Alejandro, Foster, Matthew T., Loughrey, David, Blanchard, Emmeline L., Islam, Fatima Z., Gan, Zubao, Mantalaris, Athanasios, Santangelo, Philip J., Dahlman, James E.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375820/
https://ncbi.nlm.nih.gov/pubmed/32743074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba5672
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items