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Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant phenotype

Hepatoma cell lines are widely used to model the hepatocyte for insulin signaling and fatty liver disease. However, a direct comparison of insulin action in primary hepatocytes and in hepatoma cell lines is needed to validate this model and to better understand liver cancer. Here we have investigate...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Molinaro, Angela, Becattini, Barbara, Solinas, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374613/
https://ncbi.nlm.nih.gov/pubmed/32694512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68721-9
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