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Antisense targeting of decoy exons can reduce intron retention and increase protein expression in human erythroblasts
The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger introns (>1 kb). Splicing reporter studies have shown that decoy splice sites are essential for activity, suggesting that decoys act by engaging intron-terminal splice sites...
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| Publicat a: | RNA |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7373989/ https://ncbi.nlm.nih.gov/pubmed/32312846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.075028.120 |
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