Triptonide Modulates MAPK Signaling Pathways and Exerts Anticancer Effects via ER Stress-Mediated Apoptosis Induction in Human Osteosarcoma Cells

BACKGROUND: Osteosarcoma (OS) is the most common primary malignancy arise from bone and is one of the causes of cancer-related deaths. Triptonide (TN), a diterpenoid epoxide presented in Tripterygium wilfordii, is shown to possess a broad spectrum of biological properties. METHODS: In this study, we...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Zheng, Liyun, Fang, Shiji, Hui, Junguo, Rajamanickam, Vinothkumar, Chen, Minjiang, Weng, Qiaoyou, Wu, Xulu, Zhao, Zhongwei, Ji, Jiansong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373419/
https://ncbi.nlm.nih.gov/pubmed/32765093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S258203
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