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The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population
BACKGROUND: Melanocortin 4 receptor (MC4R) deficiency, caused by mutations in MC4R, is the most common cause of monogenic forms of obesity. However, these mutations have often been identified in small-scale, case-focused studies. Here, we assess the penetrance of previously reported MC4R mutations a...
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| Publicado no: | PLoS Med |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7373259/ https://ncbi.nlm.nih.gov/pubmed/32692746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003196 |
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