Inhibition of the Super Elongation Complex Suppresses Herpes Simplex Virus Immediate Early Gene Expression, Lytic Infection, and Reactivation from Latency

Induction of herpes simplex virus (HSV) immediate early (IE) gene transcription promotes the initiation of lytic infection and reactivation from latency in sensory neurons. IE genes are transcribed by the cellular RNA polymerase II (RNAPII) and regulated by multiple transcription factors and coactiv...

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Veröffentlicht in:mBio
Hauptverfasser: Alfonso-Dunn, Roberto, Arbuckle, Jesse H., Vogel, Jodi L., Kristie, Thomas M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373197/
https://ncbi.nlm.nih.gov/pubmed/32518191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01216-20
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