Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis

The bacterial microbiome of human body sites, previously considered sterile, remains highly controversial because it can be challenging to isolate signal from noise when low-biomass samples are being analyzed. We tested the hypothesis that stochastic sequencing noise, separable from reagent contamin...

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Bibliographic Details
Published in:mBio
Main Authors: Erb-Downward, John R., Falkowski, Nicole R., D’Souza, Jennifer C., McCloskey, Lisa M., McDonald, Roderick A., Brown, Christopher A., Shedden, Kerby, Dickson, Robert P., Freeman, Christine M., Stringer, Kathleen A., Foxman, Betsy, Huffnagle, Gary B., Curtis, Jeffrey L., Adar, Sara D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373192/
https://ncbi.nlm.nih.gov/pubmed/32518181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00258-20
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