Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms

mAbs are a possible adjunct to vaccination and drugs in treatment of influenza virus infection. However, questions remain whether small animal models accurately predict efficacy in humans. We have established the pig, a large natural host animal for influenza, with many physiological similarities to...

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發表在:J Immunol
Main Authors: McNee, Adam, Smith, Trevor R. F., Holzer, Barbara, Clark, Becky, Bessell, Emily, Guibinga, Ghiabe, Brown, Heather, Schultheis, Katherine, Fisher, Paul, Ramos, Stephanie, Nunez, Alejandro, Bernard, Matthieu, Graham, Simon, Martini, Veronica, Chrun, Tiphany, Xiao, Yongli, Kash, John C., Taubenberger, Jeffery K., Elliott, Sarah, Patel, Ami, Beverley, Peter, Rijal, Pramila, Weiner, David B., Townsend, Alain, Broderick, Kate E., Tchilian, Elma
格式: Artigo
語言:Inglês
出版: AAI 2020
主題:
Immunotherapy and Vaccines
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372317/
https://ncbi.nlm.nih.gov/pubmed/32591390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000429
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