Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses

Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug...

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Foilsithe in:Sci Rep
Main Authors: Sánez Tähtisalo, Heini, Ruotsalainen, Sanni, Mars, Nina, Porthan, Kimmo, Oikarinen, Lasse, Virolainen, Juha, Fyhrquist, Frej, Ripatti, Samuli, Kontula, Kimmo K., Hiltunen, Timo P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371738/
https://ncbi.nlm.nih.gov/pubmed/32686723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68878-3
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