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The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3

BACKGROUND AND AIM: The pathophysiology of rheumatoid arthritis (RA) is characterized by excess production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) by neutrophils and macrophages in synovium. Additionally, these cytoki...

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Bibliografische gegevens
Gepubliceerd in:J Orthop Surg Res
Hoofdauteurs: Kanai, Tomotake, Kondo, Naoki, Okada, Masayasu, Sano, Hiroshige, Okumura, Go, Kijima, Yasufumi, Ogose, Akira, Kawashima, Hiroyuki, Endo, Naoto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371465/
https://ncbi.nlm.nih.gov/pubmed/32131874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13018-020-01595-9
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