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Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation

Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment factor (AF). Since sialic acid alone cannot fulfill a signaling function, the virus needs to act...

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Detalles Bibliográficos
Publicado en:PLoS Pathog
Main Authors: Sieben, Christian, Sezgin, Erdinc, Eggeling, Christian, Manley, Suliana
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371231/
https://ncbi.nlm.nih.gov/pubmed/32639985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008656
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