Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Inhibition of anti-apoptotic proteins BCL-2 and MCL-1 to release pro-apoptotic protein BIM and reactivate cell death could potentially be an efficient strategy for the treatment of leukemia. Here, we show that a lncRNA, MORRBID, a selective transcriptional repressor of BIM, is overexpressed in human...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Cai, Zhigang, Aguilera, Fabiola, Ramdas, Baskar, Daulatabad, Swapna Vidhur, Srivastava, Rajneesh, Kotzin, Jonathan J., Carroll, Martin, Wertheim, Gerald, Williams, Adam, Janga, Sarath Chandra, Zhang, Chi, Henao-Mejia, Jorge, Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371151/
https://ncbi.nlm.nih.gov/pubmed/32579941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107816
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