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Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

The cellular mechanisms controlling cell fate in self-renewal tissues remain unclear. Cell cycle failure often leads to an apoptosis anti-oncogenic response. We have inactivated Cdk1 or Polo-like-1 kinases, essential targets of the mitotic checkpoints, in the epithelia of skin and oral mucosa. Here,...

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Foilsithe in:Cell Death Differ
Main Authors: Sanz-Gómez, Natalia, de Pedro, Isabel, Ortigosa, Beatriz, Santamaría, David, Malumbres, Marcos, de Cárcer, Guillermo, Gandarillas, Alberto
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370216/
https://ncbi.nlm.nih.gov/pubmed/32080348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0515-2
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