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Complex Characterization of Germline Large Genomic Rearrangements of the BRCA1 and BRCA2 Genes in High-Risk Breast Cancer Patients—Novel Variants from a Large National Center

Large genomic rearrangements (LGRs) affecting one or more exons of BRCA1 and BRCA2 constitute a significant part of the mutation spectrum of these genes. Since 2004, the National Institute of Oncology, Hungary, has been involved in screening for LGRs of breast or ovarian cancer families enrolled for...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Bozsik, Anikó, Pócza, Tímea, Papp, János, Vaszkó, Tibor, Butz, Henriett, Patócs, Attila, Oláh, Edit
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370166/
https://ncbi.nlm.nih.gov/pubmed/32629901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21134650
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