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Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples
The development of breast and ovarian cancer is strongly connected to the inactivation of the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high efficiency in the...
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| Publicado en: | Oncotarget |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5308695/ https://ncbi.nlm.nih.gov/pubmed/27533253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11259 |
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