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Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples
The development of breast and ovarian cancer is strongly connected to the inactivation of the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high efficiency in the...
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| Wydane w: | Oncotarget |
|---|---|
| Główni autorzy: | , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Impact Journals LLC
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5308695/ https://ncbi.nlm.nih.gov/pubmed/27533253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11259 |
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