The Differential Effect of Carbon Dots on Gene Expression and DNA Methylation of Human Embryonic Lung Fibroblasts as a Function of Surface Charge and Dose

This study presents a toxicological evaluation of two types of carbon dots (CD), similar in size (<10 nm) but differing in surface charge. Whole-genome mRNA and miRNA expression (RNAseq), as well as gene-specific DNA methylation changes, were analyzed in human embryonic lung fibroblasts (HEL 1246...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Sima, Michal, Vrbova, Kristyna, Zavodna, Tana, Honkova, Katerina, Chvojkova, Irena, Ambroz, Antonin, Klema, Jiri, Rossnerova, Andrea, Polakova, Katerina, Malina, Tomas, Belza, Jan, Topinka, Jan, Rossner, Pavel
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369946/
https://ncbi.nlm.nih.gov/pubmed/32635498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21134763
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