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Evaluation of the profiles of CB(1) cannabinoid receptor signalling bias using joint kinetic modelling
BACKGROUND AND PURPOSE: Biased agonism describes the ability of ligands to differentially regulate multiple signalling pathways when coupled to a single receptor. Signalling is affected by rapid agonist‐induced receptor internalisation. Hence, the conventional use of equilibrium models may not be op...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7369624/ https://ncbi.nlm.nih.gov/pubmed/32293708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15066 |
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