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Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response

The prevalence as well as the severity of dry eye disease increase with age. Memory T helper 17 (Th17) cells (CD4(+)IL-17A(+)CD44(+)) drive the chronic and relapsing course of dry eye disease. Here, we investigated the contribution of memory Th17 cells to age-related dry eye disease, and evaluated m...

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Bibliografiset tiedot
Julkaisussa:Am J Pathol
Päätekijät: Foulsham, William, Mittal, Sharad K., Taketani, Yukako, Chen, Yihe, Nakao, Takeshi, Chauhan, Sunil K., Dana, Reza
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Investigative Pathology 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369573/
https://ncbi.nlm.nih.gov/pubmed/32289288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.03.016
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