CRISPR screens in cancer spheroids identify 3D growth specific vulnerabilities

Cancer genomics studies have nominated thousands of putative cancer driver genes(1); a major challenge is to develop high-throughput and accurate models to define their functions. Here we devised a scalable cancer spheroid model and performed genome-wide CRISPR screens in 2D-monolayers and 3D lung c...

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Vydáno v:Nature
Hlavní autoři: Han, Kyuho, Pierce, Sarah E., Li, Amy, Spees, Kaitlyn, Anderson, Gray R., Seoane, Jose A., Lo, Yuan-Hung, Dubreuil, Michael, Olivas, Micah, Kamber, Roarke A., Wainberg, Michael, Kostyrko, Kaja, Kelly, Marcus R., Yousefi, Maryam, Simpkins, Scott W., Yao, David, Lee, Keonil, Kuo, Calvin J., Jackson, Peter K., Sweet-Cordero, Alejandro, Kundaje, Anshul, Gentles, Andrew J., Curtis, Christina, Winslow, Monte M., Bassik, Michael C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368463/
https://ncbi.nlm.nih.gov/pubmed/32238925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2099-x
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