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Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation without reducing the global structural stability
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease associated with aggregation of superoxide dismutase 1 (SOD1) protein. More than 160 mutations in human SOD1 have been identified in familial ALS and extensively characterized in previous studies. Here, we invest...
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| Publicado no: | PeerJ |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
PeerJ Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368427/ https://ncbi.nlm.nih.gov/pubmed/32742795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9512 |
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