Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation without reducing the global structural stability

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease associated with aggregation of superoxide dismutase 1 (SOD1) protein. More than 160 mutations in human SOD1 have been identified in familial ALS and extensively characterized in previous studies. Here, we invest...

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Detaylı Bibliyografya
Yayımlandı:PeerJ
Asıl Yazarlar: Kimura, Shintaro, Kamatari, Yuji O., Kuwahara, Yukina, Hara, Hideaki, Yamato, Osamu, Maeda, Sadatoshi, Kamishina, Hiroaki, Honda, Ryo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: PeerJ Inc. 2020
Konular:
Biochemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368427/
https://ncbi.nlm.nih.gov/pubmed/32742795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9512
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