A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Genetic variation at the 8q24 locus is linked with the greater susceptibility to prostate cancer in men of African ancestry. One such African ancestry specific rare variant, rs72725854 (A>G/T) (~6% allele frequency) has been associated with a ~2-fold increase in prostate cancer risk. However, the...

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Vydáno v:Nat Commun
Hlavní autoři: Walavalkar, Kaivalya, Saravanan, Bharath, Singh, Anurag Kumar, Jayani, Ranveer Singh, Nair, Ashwin, Farooq, Umer, Islam, Zubairul, Soota, Deepanshu, Mann, Rajat, Shivaprasad, Padubidri V., Freedman, Matthew L., Sabarinathan, Radhakrishnan, Haiman, Christopher A., Notani, Dimple
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368061/
https://ncbi.nlm.nih.gov/pubmed/32680982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17325-y
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