Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation

BACKGROUND: Bisphosphonates have very low bioavailability and cause irritation of the esophagus and stomach. This study was planned to improve the oral bioavailability of ibandronate through the formation of a raft in the stomach. Bisphosphonate-induced irritation of the esophagus and stomach is pre...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Int J Nanomedicine
Autori principali: Hanif, Muhammad, Shah, Shahid, Rasul, Akhtar, Abbas, Ghulam, Zaman, Muhammad, Amjad, Muhammad Wahab, Abdul Ghafoor Raja, Maria, Khan, Hafeez Ullah, Ashfaq, Mehran, Iqbal, Omeira
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367921/
https://ncbi.nlm.nih.gov/pubmed/32764922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S255278
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