3′-Terminal 2′-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2

Methylation of miRNAs at the 2′-hydroxyl group on the ribose at 3′-end (2′-O-methylation, 2′Ome) is critical for miRNA function in plants and Drosophila. Whether this methylation phenomenon exists for mammalian miRNA remains unknown. Through LC–MS/MS analysis, we discover that majority of miR-21-5p...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Liang, Hongwei, Jiao, Zichen, Rong, Weiwei, Qu, Shuang, Liao, Zhicong, Sun, Xinlei, Wei, Yao, Zhao, Quan, Wang, Jun, Liu, Yuan, Chen, Xi, Wang, Tao, Zhang, Chen-Yu, Zen, Ke
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367198/
https://ncbi.nlm.nih.gov/pubmed/32542340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa504
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