STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

Oncosuppressor TP53 and oncogene STAT3 have been shown to engage an interplay in which they negatively influence each other. Conversely, mutant (mut) p53 may sustain STAT3 phosphorylation by displacing SH2 phosphatase while whether STAT3 could influence mutp53 has not been clarified yet. In this stu...

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Benedetti, Rossella, Santarelli, Roberta, D'Orazi, Gabriella, Cirone, Mara
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367154/
https://ncbi.nlm.nih.gov/pubmed/32754441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01102
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