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Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a S(N)Ar Reaction Toward Trends in Reaction Pathways

The mechanism of S(N)Ar reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Brönsted-type plots analysis. The first appr...

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Udgivet i:Front Chem
Main Authors: Campodónico, Paola R., Olivares, Belén, Tapia, Ricardo A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366874/
https://ncbi.nlm.nih.gov/pubmed/32754575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00583
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