Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes

Rapidly increasing availability of genomic data and ensuing identification of disease associated mutations allows for an unbiased insight into genetic drivers of disease development. However, determination of molecular mechanisms by which individual genomic changes affect biochemical processes remai...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Mehnert, Martin, Ciuffa, Rodolfo, Frommelt, Fabian, Uliana, Federico, van Drogen, Audrey, Ruminski, Kilian, Gstaiger, Matthias, Aebersold, Ruedi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366679/
https://ncbi.nlm.nih.gov/pubmed/32678104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17387-y
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