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Glycine substitution in SH3-SH2 connector of Hck tyrosine kinase causes population shift from assembled to disassembled state

A combination of small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations based on a coarse grained model is used to examine the effect of glycine substitutions in the short connector between the SH3 and SH2 domains of Hck, a member of the Src-family kinases. It has been shown pre...

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Publicat a:Biochim Biophys Acta Gen Subj
Autors principals: Huang, Lei, Wright, Michelle, Yang, Sichun, Blachowicz, Lydia, Makowski, Lee, Roux, Benoît
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7366498/
https://ncbi.nlm.nih.gov/pubmed/32224253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2020.129604
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