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Glycine substitution in SH3-SH2 connector of Hck tyrosine kinase causes population shift from assembled to disassembled state
A combination of small angle X-ray scattering (SAXS) and molecular dynamics (MD) simulations based on a coarse grained model is used to examine the effect of glycine substitutions in the short connector between the SH3 and SH2 domains of Hck, a member of the Src-family kinases. It has been shown pre...
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| Publicado no: | Biochim Biophys Acta Gen Subj |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7366498/ https://ncbi.nlm.nih.gov/pubmed/32224253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2020.129604 |
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